A feasibility test of an online intervention to prevention dating violence in emerging adults

Dating violence in emerging adults is a significant problem and few prevention programs based on the developmental needs of this age group have been developed. Our research team developed an online dating violence prevention program called WISER (Writing to Improve Self-in-Relationships) for emerging adults. The program is based on narrative therapy principles and uses structured writing techniques. A single group pre-post feasibility test of WISER was conducted with 14 college women. WISER was demonstrated to be feasible and acceptable and to show promise as an effective program to decrease dating violence in this population

Designing an Internet Intervention for Emerging Adults Who Experience Troubled Relationships

This article describes how the Internet Intervention Model (IIM) was used as an organizing framework to design a theoretically based Internet intervention for emerging adults who experience troubled intimate partner relationships. In the design process, the team addressed six fundamental questions related to the several components of the IIM. Decisions made regarding the design of the intervention based on the six questions are described. We focus in particular on how the intervention is based on the Theory of Emerging Adulthood and the Theory of Narrative Identity

Call to Action: The Impact of Cyberbullying in the COVID Era

Given the recent COVID-19 pandemic, research suggests that students are spending an increased amount of time online. Consequently, the opportunity for students engaged in, or students who are a victim of cyberbullying has increased as well. Bullying no longer begins and ends with the school bells, it has infiltrated every aspect of students’ lives through the internet. Similarly, to bullying, cyberbullying leads to negative outcomes; the purpose of this article is to identify support, prevention, and intervention suggestions for parents, educators and schools, and mental health providers to decrease students’ cyberbullying involvement

Cardiac Implantable Electronic Device Reutilization: Battery Life of Explanted Devices at a Tertiary Care Center

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106926/1/pace12321.pd

Acumulaciones y Diagramas de Niveles y Flujos

Existen varias características de los sistemas complejos que dificultan la creación de cambios en la salud de la comunidad, los cuales incluyen los siguientes: retrasos entre la intervención y el resultado, respuestas inesperadas o confusas a intervenciones, y diferencias en las formas en que los individuos y los grupos experimentan el mismo sistema. El concepto de “acumulación” brinda información importante sobre la forma en que se generan las percepciones erróneas, retrasos y respuestas contradictorias al sistema dentro de los esfuerzo de la salud que se llevan a cabo. Los diagramas de niveles y flujos son herramientas que sirven para identificar y describir visualmente acumulaciones importantes en el sistema, y para facilitar el diálogo para comprender mejor el sistema. El propósito de este breve documento es describir el concepto de las acumulaciones y su utilidad para ayudarnos a comprender el comportamiento del sistema, y mostrarnos la forma en que los diagramas de niveles y flujos pueden ser utilizados para ayudarnos a modelar problemas y encontrar soluciones en el sistema alimentario y de salud

Harmonisation of short-term in vitro culture for the expansion of antigen-specific CD8+ T cells with detection by ELISPOT and HLA-multimer staining

Ex vivo ELISPOT and multimer staining are well-established tests for the assessment of antigen-specific T cells. Many laboratories are now using a period of in vitro stimulation (IVS) to enhance detection. Here, we report the findings of a multi-centre panel organised by the Association for Cancer Immunotherapy Immunoguiding Program to investigate the impact of IVS protocols on the detection of antigen-specific T cells of varying ex vivo frequency. Five centres performed ELISPOT and multimer staining on centrally prepared PBMCs from 3 donors, both ex vivo and following IVS. A harmonised IVS protocol was designed based on the best-performing protocol(s), which was then evaluated in a second phase on 2 donors by 6 centres. All centres were able to reliably detect antigen-specific T cells of high/intermediate frequency both ex vivo (Phase I) and post-IVS (Phase I and II). The highest frequencies of antigen-specific T cells ex vivo were mirrored in the frequencies following IVS and in the detection rates. However, antigen-specific T cells of a low/undetectable frequency ex vivo were not reproducibly detected post-IVS. Harmonisation of the IVS protocol reduced the inter-laboratory variation observed for ELISPOT and multimer analyses by approximately 20 %. We further demonstrate that results from ELISPOT and multimer staining correlated after (P < 0.0001 and R(2) = 0.5113), but not before IVS. In summary, IVS was shown to be a reproducible method that benefitted from method harmonisation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00262-014-1593-0) contains supplementary material, which is available to authorized users

Modelos Mentales

Un principio central de la perspectiva del pensamiento sistémico es que las estructuras del sistema están respaldadas y permanecen por nuestras creencias, formas de pensar, y objetivos subyacentes (Ver Serie de Informes de Métodos 1.08). Por lo tanto, para transformar y rediseñar los sistemas también debemos transformar nuestra mentalidad. El propósito de este breve documento es introducir el concepto de modelos mentales y discutir cómo las herramientas de dinámica de sistemas se pueden usar para identificarlos, negociarlos y transformarlos

Directed evolution of a magnetic resonance imaging contrast agent for noninvasive imaging of dopamine

The development of molecular probes that allow in vivo imaging of neural signaling processes with high temporal and spatial resolution remains challenging. Here we applied directed evolution techniques to create magnetic resonance imaging (MRI) contrast agents sensitive to the neurotransmitter dopamine. The sensors were derived from the heme domain of the bacterial cytochrome P450-BM3 (BM3h). Ligand binding to a site near BM3h's paramagnetic heme iron led to a drop in MRI signal enhancement and a shift in optical absorbance. Using an absorbance-based screen, we evolved the specificity of BM3h away from its natural ligand and toward dopamine, producing sensors with dissociation constants for dopamine of 3.3–8.9 μM. These molecules were used to image depolarization-triggered neurotransmitter release from PC12 cells and in the brains of live animals. Our results demonstrate the feasibility of molecular-level functional MRI using neural activity–dependent sensors, and our protein engineering approach can be generalized to create probes for other targets.Charles A. Dana Foundation. Brain and Immuno-ImagingRaymond and Beverley Sackler FoundationNational Institutes of Health (U.S.) (grant R01-DA28299)National Institutes of Health (U.S.) (grant DP2-OD2441)National Institutes of Health (U.S.) (grant R01-GM068664)Jacobs Institute for Molecular Engineering for Medicine. Jacobs Institute for Molecular Engineering for MedicineNational Institutes of Health (U.S.) (grant R01-DE013023

Constraints on the χ_(c1) versus χ_(c2) polarizations in proton-proton collisions at √s = 8 TeV

The polarizations of promptly produced χ_(c1) and χ_(c2) mesons are studied using data collected by the CMS experiment at the LHC, in proton-proton collisions at √s=8  TeV. The χ_c states are reconstructed via their radiative decays χ_c → J/ψγ, with the photons being measured through conversions to e⁺e⁻, which allows the two states to be well resolved. The polarizations are measured in the helicity frame, through the analysis of the χ_(c2) to χ_(c1) yield ratio as a function of the polar or azimuthal angle of the positive muon emitted in the J/ψ → μ⁺μ⁻ decay, in three bins of J/ψ transverse momentum. While no differences are seen between the two states in terms of azimuthal decay angle distributions, they are observed to have significantly different polar anisotropies. The measurement favors a scenario where at least one of the two states is strongly polarized along the helicity quantization axis, in agreement with nonrelativistic quantum chromodynamics predictions. This is the first measurement of significantly polarized quarkonia produced at high transverse momentum